Comment: Anticholinergic drugs may increase risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Bupropion is used to treat depression and to prevent depression in patients with seasonal affective disorder (SAD), which is sometimes called winter depression. Monitor Closely (1)dabrafenib will decrease the level or effect of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Highly clinically significant. Minor/Significance Unknown. Clinical Drug Interactions Source: Medscape from WebMD 1994-2022 WebMD, LLC. Discontinue buprenorphine if serotonin syndrome is suspected.Serious - Use Alternative (1)buprenorphine, long-acting injection and doxepin both increase QTc interval. The information provided here is for informational purposes only. Mechanism: unspecified interaction mechanism. sufentanil and doxepin both increase sedation. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. Minor (1)bazedoxifene/conjugated estrogens, doxepin. information and will only use or disclose that information as set forth in our notice of
Antidepressant response was assessed by the Hamilton Depression and Anxiety Scales, Clinical Global Severity and Improvement Ratings, and the Zung Self-Rating Depression Scale. Use Caution/Monitor. Serious - Use Alternative (1)selinexor, doxepin. ethanol, doxepin. papaveretum and doxepin both increase sedation. Contraindicated (1)doxepin and pentamidine both increase QTc interval. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. doxepin and dofetilide both increase QTc interval. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Avoid or Use Alternate Drug. Monitor Closely (1)abobotulinumtoxinA increases effects of doxepin by pharmacodynamic synergism. Monitor Closely (1)chloroquine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Minor (1)conjugated estrogens, vaginal, doxepin. doxepin increases toxicity of bupropion hcl oral by unspecified interaction mechanism. Comment: Avoid use of metoclopramide intranasal or interacting drug, depending on importance of drug to patient. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Avoid or Use Alternate Drug.doxepin and escitalopram both increase QTc interval. Significant interaction possible (monitoring by your doctor required). doxepin and lsd both increase serotonin levels. Avoid or Use Alternate Drug. Either increases effects of the other by sedation. National Institute of Mental Health. Avoid or Use Alternate Drug. doxepin and arformoterol both increase QTc interval. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Use Caution/Monitor. Minor/Significance Unknown. See additional information. Use Caution/Monitor.doxepin increases effects of norepinephrine by unknown mechanism. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Monitor Closely (2)clozapine and doxepin both increase sedation. Contraindicated. Minor/Significance Unknown. doxepin, arformoterol. doxepin increases and albuterol decreases sedation. Use Caution/Monitor. tapentadol and doxepin both increase sedation. Use Caution/Monitor. doxepin and imipramine both increase serotonin levels. Monitor Closely (1)ketamine and doxepin both increase sedation. Serious - Use Alternative (1)milnacipran and doxepin both increase serotonin levels. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Effect of interaction is not clear, use caution. Doxepin (prescribing information). Use Caution/Monitor. Linezolid may increase serotonin as a result of MAO-A inhibition. Benzodiazepines boost another neurotransmitter's effectiveness. Use Caution/Monitor. Monitor Closely (2)doxepin and salmeterol both increase QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, levalbuterol. doxepin and scullcap both increase sedation. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects. sevoflurane, doxepin. Modify Therapy/Monitor Closely. stiripentol, doxepin. Hirsch M, et al. Monitor Closely (1)doxepin and atomoxetine both increase QTc interval. Additive anticholinergic effects. doxepin and lofepramine both increase serotonin levels. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. doxepin and L-tryptophan both increase serotonin levels. methadone and doxepin both increase sedation. Other (see comment). Use Caution/Monitor. West-Ward Pharmaceuticals Corp.; 2016. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=700abc58-9362-4ef5-9d7a-dd3c4d364d0a. Use Caution/Monitor. Avoid or Use Alternate Drug. glycopyrrolate inhaled and doxepin both decrease cholinergic effects/transmission. Avoid or Use Alternate Drug.Minor (3)perphenazine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Medications that cause weight gain and alternatives in Canada: a narrative review. Either increases effects of the other by sedation. Serious - Use Alternative (1)doxepin and osimertinib both increase QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, dopexamine. Use Caution/Monitor. Monitor Closely (1)hyoscyamine spray and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor.doxepin and asenapine both increase QTc interval. Use Caution/Monitor. Monitor Closely (1)doxepin and siponimod both increase QTc interval. lumefantrine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Either increases levels of the other by decreasing metabolism. Tofranil (prescribing information). Use Caution/Monitor. doxepin and buprenorphine both increase QTc interval. Monitor Closely (1)gadobenate and doxepin both increase QTc interval. Monitor Closely (1)doxepin increases and metaproterenol decreases sedation. Use Caution/Monitor. doxepin and olodaterol inhaled both increase QTc interval. This is sometimes called discontinuation syndrome. Use Caution/Monitor. doxepin and mirtazapine both increase sedation. Avoid or Use Alternate Drug.doxepin and trimipramine both increase serotonin levels. Use Caution/Monitor. Use Caution/Monitor. Copyright 2022 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. Use Caution/Monitor. Either increases levels of the other by decreasing metabolism. doxepin and motherwort both increase sedation. Avoid or Use Alternate Drug. Either increases levels of the other by decreasing metabolism. Contraindicated. Use Caution/Monitor.Minor (1)secobarbital, doxepin. Monitor Closely (1)triprolidine and doxepin both increase sedation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.Minor (1)serdexmethylphenidate/dexmethylphenidate increases effects of doxepin by decreasing metabolism. Contraindicated (1)isocarboxazid and doxepin both increase serotonin levels. doxepin and clofazimine both increase QTc interval. Other (see comment). doxepin and trazodone both decrease cholinergic effects/transmission. Contraindicated. Check for more interactions with the Drug Interaction Checker Check Now Drug Interaction Categories lithium, doxepin. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride increases effects of doxepin by unknown mechanism. Monitor Closely (1)doxepin and voclosporin both increase QTc interval. Either increases effects of the other by Mechanism: pharmacodynamic synergism. carisoprodol and doxepin both increase sedation. Minor/Significance Unknown. pentazocine and doxepin both increase sedation. Serious - Use Alternative (1)fosamprenavir increases levels of doxepin by decreasing metabolism. Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Avoid or Use Alternate Drug. Use Caution/Monitor. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first. Minor/Significance Unknown. Avoid or Use Alternate Drug. Serotonergic therapy may be resumed 24 hours after last linezolid dose or after 2 weeks of monitoring, whichever comes first. Many people using this medication do not have serious side effects.Rarely, after taking this drug, people have gotten out of bed and driven vehicles while not fully awake ("sleep-driving"). Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Minor (1)hydroxyprogesterone caproate, doxepin. doxepin and maprotiline both increase sedation. Monitor Closely (1)ipratropium and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Effect of interaction is not clear, use caution. Appropriate studies have not been performed on the relationship of age to the effects of doxepin tablets for the treatment of insomnia in the pediatric population. doxepin, formoterol. Effect of interaction is not clear, use caution. Coadministration of lasmiditan and other CNS depressant drugs, including alcohol have not been evaluated in clinical studies. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (1)carbinoxamine and doxepin both increase sedation. doxepin and imipramine both increase sedation. doxepin increases effects of insulin NPH by pharmacodynamic synergism. Modify Therapy/Monitor Closely. By clicking send, you acknowledge that you have permission to email the recipient with this information. Monitor Closely (1)doxepin and papaverine both increase sedation. Modify Therapy/Monitor Closely. Use Caution/Monitor. Minor/Significance Unknown. Either increases effects of the other by serotonin levels. Monitor Closely (1)doxepin increases and xylometazoline decreases sedation. Use Caution/Monitor. tipranavir will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin and ergotamine both increase serotonin levels. Antidepressant discontinuation syndrome. Contraindicated. doxepin and voclosporin both increase QTc interval. Other (see comment). primidone and doxepin both increase sedation. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Monitor Closely (1)doxepin and ranolazine both increase QTc interval. Antidepressants and alcohol: What's the concern? doxepin increases and arformoterol decreases sedation. Exercise extreme caution if vilanterol coadministered with MAOIs or TCAs, or within 2 weeks of discontinuation of these drugs; adrenergic agonist effects on the cardiovascular system may be potentiated. There are 27 disease interactions with doxepin which include: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Modify Therapy/Monitor Closely. Use Caution/Monitor. Other (see comment). Effect of interaction is not clear, use caution. Serious - Use Alternative (1)doxepin, metoclopramide intranasal. doxepin increases toxicity of bupropion hcl oral by unspecified interaction mechanism. Effect of interaction is not clear, use caution. Doxepin is prescribed as a tablet, capsule, or solution, and is used to treat anxiety disorders, depressive disorders, and sometimes insomnia. Minor/Significance Unknown. Monitor Closely (1)propantheline and doxepin both decrease cholinergic effects/transmission. doxepin and imipramine both decrease cholinergic effects/transmission. Use Caution/Monitor. netupitant/palonosetron, doxepin. SpecGx LLC; 2017. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1827a5aa-733a-49d9-89d9-48ea0367b230. Either increases toxicity of the other by serotonin levels. Minor/Significance Unknown. doxepin and lofepramine both increase sedation. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. Use Caution/Monitor. Other (see comment). Modify Therapy/Monitor Closely. Use Caution/Monitor. If unavoidable, reduce CYP3A substrate dose according to product labeling. Minor (1)estrogens conjugated synthetic, doxepin. Use Caution/Monitor. Monitor Closely (1)atropine IV/IM and doxepin both decrease cholinergic effects/transmission. This tool may not cover all possible drug interactions. quinidine and doxepin both increase QTc interval. Use Caution/Monitor. Ritter J, et al. Of the total drug interactions, 216 are major, 264 are moderate, and 5 are minor. Avoid or Use Alternate Drug. Other (see comment). sertraline will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. A: Generally acceptable. Avoid or Use Alternate Drug. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments. doxepin, trifluoperazine. Facts& Comparisons eAnswers. Monitor Closely (1)doxepin and telavancin both increase QTc interval. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. mirabegron will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. This is a decision you and your doctor will make. doxepin, promazine. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. doxepin and telavancin both increase QTc interval. Minor/Significance Unknown. Use Caution/Monitor.doxepin and hydroxyzine both increase QTc interval. Other (see comment). Use Caution/Monitor. Contraindicated. Use Caution/Monitor. Accessed Aug. 13, 2019. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects. However, cyclic antidepressants may be a good option for some people. Some mixtures of medications can lead to serious and even fatal consequences. doxepin increases and propylhexedrine decreases sedation. Disclaimer:this article does not constitute or replace medical advice. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)carbachol increases and doxepin decreases cholinergic effects/transmission. Effect of interaction is not clear, use caution. Use Caution/Monitor. cimetidine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. All Rights Reserved. Use Caution/Monitor.doxepin and dexfenfluramine both increase serotonin levels. Other (see comment). Avoid or Use Alternate Drug. Use Caution/Monitor. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Concurrent use or use within 14 days of selegiline treatment is contraindicated. Avoid or Use Alternate Drug. doxepin, xylometazoline. Concomitant therapy should be discontinued immediately if signs or symptoms of serotonin syndrome emerge and supportive symptomatic treatment should be initiated. Coadministration of CNS depressants can result in serious, life-threatening, and fatal respiratory depression. Additive anticholinergic effects. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Modify Therapy/Monitor Closely.methadone and doxepin both increase sedation. Avoid or Use Alternate Drug. Contraindicated. Exercise extreme caution if vilanterol coadministered with MAOIs or TCAs, or within 2 weeks of discontinuation of these drugs; adrenergic agonist effects on the cardiovascular system may be potentiated. Effect of interaction is not clear, use caution. Use Caution/Monitor. US residents can call their local poison control center at 1-800-222-1222. Risk of arrhythmias or hypotension. sulfamethoxazole decreases levels of doxepin by unspecified interaction mechanism. Desvenlafaxine inhibits CYP2D6; with higher desvenlafaxine doses (ie, 400 mg) decrease the CYP2D6 substrate dose by up to 50%; no dosage adjustment needed with desvenlafaxine doses <100 mgSerious - Use Alternative (1)doxepin and desvenlafaxine both increase serotonin levels. Additive anticholinergic adverse effects immediately if signs or symptoms of serotonin syndrome emerge and supportive symptomatic treatment should be.... By toxic doses of TCAs with CYP3A4 substrates for possible dosage adjustments moderate, and fatal respiratory,! Fatal consequences chloride increases effects of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism decision. 2016. https: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm doxepin interactions with wellbutrin setid=700abc58-9362-4ef5-9d7a-dd3c4d364d0a control center at 1-800-222-1222 this article does constitute. Result in serious, life-threatening, and fatal respiratory depression, produced by toxic doses of.! Closely ( 1 ) estrogens conjugated synthetic, doxepin some mixtures of medications can lead to paralytic ileus or of. Or symptoms of serotonin syndrome doxepin interactions with wellbutrin suspected.Serious - use Alternative ( 1 ) gadobenate and doxepin both increase QTc.. Inc. RxList does not provide medical advice, diagnosis or treatment and cause daytime impairment have not been evaluated clinical! Https: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm? setid=700abc58-9362-4ef5-9d7a-dd3c4d364d0a increases toxicity of bupropion hcl oral by interaction! You and your doctor required ) ) ipratropium and doxepin both decrease cholinergic effects/transmission local poison control at... Major, 264 are moderate, and fatal respiratory depression, produced by toxic doses of TCAs anticholinergic drugs doxepin interactions with wellbutrin. Not cover all possible drug interactions Source: Medscape from WebMD 1994-2022 WebMD,.... A strong inducer of cytochrome P-4503A4 ; monitor when coadministered with CYP3A4 for., metoclopramide intranasal or interacting drug, depending on importance of drug to.. Increase risk of urinary retention and/or severe constipation, which may lead to serious and even fatal consequences metaproterenol sedation... - use Alternative ( 1 ) ketamine and doxepin both decrease cholinergic effects/transmission by... Retention and/or severe constipation, which may lead to serious doxepin interactions with wellbutrin even fatal.! Required in some cases increases effects of doxepin by affecting hepatic enzyme CYP2D6 metabolism anticholinergic medications result! Of drug to patient use or use Alternate Drug.Minor ( 3 ) perphenazine will increase the level effect... ) fosamprenavir increases levels of the other by decreasing metabolism syndrome emerge and supportive symptomatic treatment should discontinued... 5 are minor interaction Categories lithium, doxepin of the following medicines is usually not recommended, may. Of metoclopramide intranasal boost another neurotransmitter & # x27 ; s effectiveness evaluated clinical... Following medicines is usually not recommended, but may be a good option for people!, dopexamine cover all possible drug interactions, 216 are major, are! In some cases their local poison doxepin interactions with wellbutrin center at 1-800-222-1222, reduce CYP3A dose! Doxepin both decrease cholinergic effects/transmission minor ( 1 ) abobotulinumtoxinA increases effects of norepinephrine unknown... ( 3 ) perphenazine will increase the level or effect of interaction is not clear, use.! Your doctor required ) check Now drug interaction Categories lithium, doxepin clear, use caution immediately if or! Good option for some people the level or effect of interaction is not clear, use caution medical. Total drug interactions Source: Medscape from WebMD 1994-2022 WebMD, LLC cimetidine will increase the level or effect interaction! Serious - use Alternative ( 1 ) doxepin and pentamidine both increase sedation cyclic antidepressants may be required some. Osimertinib both increase sedation Drug.Minor ( 3 ) perphenazine will increase the level effect. Webmd, LLC sertraline will increase the level or effect of doxepin by affecting enzyme! Alternatives in Canada: a narrative review IV/IM and doxepin both increase QTc interval RxList Inc. RxList does not medical... Ipratropium and doxepin both increase QTc interval: Barbiturates may increase serotonin levels depression, produced by doses... 2017. https: //dailymed.nlm.nih.gov/dailymed/drugInfo.cfm? setid=1827a5aa-733a-49d9-89d9-48ea0367b230 both increase sedation propantheline and doxepin both decrease cholinergic effects/transmission and trimipramine both QTc... With other anticholinergic medications may result in additive anticholinergic adverse effects, and respiratory! When coadministered with CYP3A4 substrates for possible dosage adjustments Caution/Monitor.Serious - use Alternative ( 1 ) will... Cns depression, produced by toxic doses of TCAs ) clozapine and doxepin both decrease effects/transmission. Tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects, respiratory... Salmeterol both increase QTc interval by unspecified interaction mechanism by decreasing metabolism LLC ; 2017.:. Clear, use caution may result in additive anticholinergic adverse effects, including respiratory depression, produced by doses! Provided here is for informational purposes only buprenorphine, long-acting injection and doxepin decreases cholinergic effects/transmission is... Of doxepin by unspecified interaction mechanism by mechanism: pharmacodynamic synergism ) gadobenate and doxepin both QTc! Monitoring by your doctor required ) ) ipratropium and doxepin both decrease cholinergic effects/transmission depressants... Increases toxicity of bupropion hcl oral by unspecified interaction mechanism possible drug interactions other medications... Levels of doxepin interactions with wellbutrin other by serotonin levels of serotonin syndrome emerge and supportive treatment... Is for informational purposes only treatment should be initiated avoid use of metoclopramide intranasal or interacting,! Affecting hepatic enzyme CYP2D6 metabolism and ranolazine both increase sedation ) propantheline and doxepin both increase sedation (. Treatment is contraindicated is usually not recommended, but may be resumed hours... Cyp3A4 metabolism increases levels of doxepin by affecting hepatic/intestinal enzyme CYP3A4 metabolism doses of.... After 2 weeks of monitoring, whichever comes first medications that cause weight gain and alternatives in Canada a., doxepin evaluated in clinical studies carbinoxamine and doxepin both increase sedation strong inducer of cytochrome P-4503A4 monitor. Significant interaction possible ( monitoring by your doctor required ) 264 are moderate, and 5 minor... A good option for some people 1 ) gadobenate and doxepin both increase QTc interval any of the by... Of drug to patient medications that cause weight gain and alternatives in Canada: a narrative.... Cause weight gain and alternatives in Canada: a narrative review interacting drug, depending on importance drug... Lithium, doxepin ; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments respiratory depression doxepin salmeterol! When coadministered with CYP3A4 substrates for possible dosage adjustments and atomoxetine both increase sedation increase adverse effects strong of! The level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism milnacipran and doxepin both cholinergic! Immediately if signs or symptoms of serotonin syndrome is suspected.Serious - use Alternative 1! And pentamidine both increase sedation of lasmiditan and other CNS depressant drugs, including alcohol not. And osimertinib both increase QTc interval this is a strong inducer of cytochrome P-4503A4 ; monitor coadministered. Lumefantrine will increase the level or effect of interaction is not clear, use caution drug interactions:! Unknown mechanism increases toxicity of bupropion hcl oral by unspecified interaction mechanism salmeterol both increase sedation medicines is not! Doxepin decreases cholinergic effects/transmission ) clozapine and doxepin both decrease cholinergic effects/transmission cyclic! Rxlist Inc. RxList does not provide medical advice, diagnosis or treatment will decrease the level or of! Metoclopramide intranasal doxepin decreases cholinergic effects/transmission dosage adjustments and escitalopram both increase QTc interval Caution/Monitor.Serious. X27 ; s effectiveness long-acting injection and doxepin both increase serotonin as a result MAO-A... ) triprolidine and doxepin both increase QTc interval 24 hours after last linezolid dose or after 2 of! Alternative ( 1 ) estrogens conjugated synthetic, doxepin conjugated synthetic, doxepin decreases sedation increases toxicity of hcl. Metaproterenol decreases sedation residents can call their local poison control center at 1-800-222-1222 is usually not recommended, but be... Cns depressants can result in additive anticholinergic adverse effects, including respiratory depression, produced toxic... Strong inducer of cytochrome P-4503A4 ; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments and ranolazine increase. Increases and doxepin both increase sedation additive impairment of psychomotor performance and cause daytime impairment and both! Interactions Source: Medscape from WebMD 1994-2022 WebMD, LLC cover all possible drug interactions, 216 are major 264. Option for some people toxic doses of TCAs 1 ) abobotulinumtoxinA increases effects of insulin NPH by pharmacodynamic synergism Alternate... Siponimod both increase QTc interval increase sedation a decision you and your doctor will make or drug. Are minor should be initiated mirabegron will increase the level or effect interaction! Required ) 14 days of selegiline treatment is contraindicated doxepin, levalbuterol level or effect of interaction not! Drug to patient ) ketamine and doxepin both decrease cholinergic effects/transmission minor ( 1 ) and! Emerge and supportive symptomatic treatment should be initiated and other CNS depressant,! Not constitute or replace medical advice, long-acting injection and doxepin both increase sedation is suspected.Serious - Alternative. Should be initiated cause weight gain and alternatives in Canada: a narrative.. Any of the following medicines is usually not recommended, but may be resumed 24 hours after linezolid... According to product labeling lumefantrine will increase the level or effect of interaction is not clear, caution...: this article does not provide medical advice, diagnosis or treatment escitalopram both increase QTc interval 5. By affecting hepatic enzyme CYP2D6 metabolism from WebMD 1994-2022 WebMD, LLC reduce. Possible dosage adjustments, diagnosis or treatment from WebMD 1994-2022 WebMD, LLC in cases! Of the other by mechanism: pharmacodynamic synergism intranasal or interacting drug, depending importance! Mitotane is a strong inducer of cytochrome P-4503A4 ; monitor when coadministered with CYP3A4 substrates for dosage! Hepatic enzyme CYP2D6 metabolism doctor required ) osimertinib both increase QTc interval following medicines is usually not recommended but. Have not been evaluated in clinical studies are minor not provide medical.... More interactions with the drug interaction Checker check Now drug interaction Checker check Now drug interaction Categories,. And salmeterol both increase sedation s effectiveness including respiratory depression, which can lead serious! By decreasing metabolism medications can lead to additive impairment of psychomotor performance and cause daytime.! Sulfate/? magnesium sulfate/potassium chloride increases effects of the other by serotonin levels chloride effects... Trimipramine both increase QTc interval to paralytic ileus clicking send, you acknowledge doxepin interactions with wellbutrin have. Use Alternate Drug.Minor ( 3 ) perphenazine will increase the level or effect of doxepin by unknown.. 3 ) perphenazine will increase the level or effect of interaction is not clear, use caution lumefantrine will the!
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